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"CCR5-delta32" is a deletion mutation of a gene which only 1% of the total population has two copies of this gene and individuals who carry two copies of this genetic mutation are immune to Smallpox, The Bubonic Plague (Black Death) and HIV, the virus that causes AIDS. Up to 20% of the population carry only one copy of this genetic mutation depending on your background and although they still run a significant risk of contracting HIV, the progress of the disease is greatly reduced and can result in a longer life expectancy.
What is CCR5-delta32?
Cysteine-cysteine chemokine receptor 5 (CCR5) is found in the cell membranes of many types of mammalian cells, including nerve cells and white blood cells. The role of CCR5 is to allow entry of chemokines into the cell—chemokines are involved in signaling the body’s inflammation response to injuries. The gene that codes for CCR5 is situated on human chromosome 3. Various mutations of the CCR5 gene are known that result in damage to the expressed receptor. One of the mutant forms of the gene is CCR5-delta32, which results from deletion of a particular sequence of 32 base-pairs. This mutant form of the gene results in a receptor so damaged that it no longer functions. But surprisingly, this does not appear to be harmful.
Why CCR5-delta32 is Resistant to HIV (Please Watch The Video Below)
This mutation can be advantageous to those individuals who carry it. The virus HIV normally enters a cell via its CCR5 receptors, especially in the initial stage of a person becoming infected. But in people with receptors crippled by the CCR5-delta32 mutation, entry of HIV by this means is blocked, providing immunity to AIDS for people with delta 32 mutation on both genes (called homozygous carriers) and greatly slowing progress of the disease in people with a delta 32 mutation on one of the two genes (called heterozygous carriers).
What is CCR5-delta32?
Cysteine-cysteine chemokine receptor 5 (CCR5) is found in the cell membranes of many types of mammalian cells, including nerve cells and white blood cells. The role of CCR5 is to allow entry of chemokines into the cell—chemokines are involved in signaling the body’s inflammation response to injuries. The gene that codes for CCR5 is situated on human chromosome 3. Various mutations of the CCR5 gene are known that result in damage to the expressed receptor. One of the mutant forms of the gene is CCR5-delta32, which results from deletion of a particular sequence of 32 base-pairs. This mutant form of the gene results in a receptor so damaged that it no longer functions. But surprisingly, this does not appear to be harmful.
Why CCR5-delta32 is Resistant to HIV (Please Watch The Video Below)
This mutation can be advantageous to those individuals who carry it. The virus HIV normally enters a cell via its CCR5 receptors, especially in the initial stage of a person becoming infected. But in people with receptors crippled by the CCR5-delta32 mutation, entry of HIV by this means is blocked, providing immunity to AIDS for people with delta 32 mutation on both genes (called homozygous carriers) and greatly slowing progress of the disease in people with a delta 32 mutation on one of the two genes (called heterozygous carriers).
